BUSPAR (buspirone hydrochloride) Tablets. DESCRIPTION. Buspirone hydrochloride tablets, USP are an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs. Buspar is used to treat anxiety and for the short term treatment of anxiety disorder. It has a direct effect on the neurotransmitters in the brain making it effective in treating mood disorders associated with addiction. Mixing Buspar And Alcohol As mentioned above, mixing buspirone with alcohol exacerbates the effects of each. This means that the sedative effects of buspirone will be higher than normal and the side effects associated with drinking alcohol will also be higher. Buspirone (BuSpar) is a prescription medication used to treat anxiety. It belongs to a group of anti-anxiety drugs called anxiolytics. It belongs to a group of anti-anxiety drugs called anxiolytics. When you drink alcohol, you might feel more relaxed or that your anxiety is temporarily relieved. However, after a few hours, when the effects of the alcohol wear off, your anxiety may feel worse. You should avoid the use of alcohol while being treated with busPIRone. Alcohol can increase the nervous system side effects of busPIRone such as dizziness, drowsiness, and difficulty concentrating. Alcohol and Buspar shouldn’t be taken together because both affect the central nervous system of the user, and they do so in similar ways. If you combine alcohol and Buspar and it can heighten the effects of both substances, leading to the increased potential for adverse side effects as well as severe harm. Combining BuSpar and alcohol may increase your risk of developing side effects, such as memory problems, drowsiness, and problems with coordination. Our Buspar Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur.